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However, this concept has been challenged: more than 95% of individuals with hereditary MPO deficiency are asymptomatic and not at increased risk for life-threatening infectious complications suggesting that the MPO oxidant system is ancillary rather than essential for phagocyte-mediated microbicidal activity

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So, we have been motivated to use fungal GT to mediate the conjugation reaction of Epothilone with glutathione to be a novel platform for one-pot synthesis of this conjugate, with an affordable anticancer activity and stability

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